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Cross-Study Findings Experience With Dosing Greater Than 10 g Of Hydroxocobalamin Across all four uncontrolled studies, 10 patients who did not demonstrate a full response to 5 or 10 g-doses of hydroxocobalamin were treated with more than 10 g of hydroxocobalamin

In some cases, alternating between them may be even better

Researchers have proposed several non-exclusive frameworks, including blood-brain-barrier transport of an endogenous peptide, interaction with the stress axis, circadian and pineal signalling via the alpha-1-adrenergic receptor (PMID 3029331), and neuroprotective activity